smacmimetic

由 YC Chang 著作 · 2020 · 被引用 30 次 — In this article, we review the anti-cancer potency and novel molecular targets of LCL161, birinapant, and GDC-0152. Preclinical studies demonstrated that Smac ...

SMAC mimetic LCL161. An orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis ...

Small-molecule Smac mimetics are being developed as a novel class of anticancer drugs. Recent studies have shown that Smac mimetics target cellular ...

Find smac mimetic and related products for scientific research at Merck.

由 MA Miles 著作 · 2020 · 被引用 6 次 — Smac mimetics, or IAP antagonists, are a class of drugs currently being evaluated as anti-cancer therapeutics. These agents antagonize IAP proteins, ...

由 L Bai 著作 · 2014 · 被引用 217 次 — SMAC mimetic, by promoting the degradation of cIAP proteins, stimulates the formation of ripoptosome and subsequent apoptosis in etoposide-treated SMAC mimetic- ...

由 N Lalaoui 著作 · 2020 · 被引用 35 次 — Smac mimetics function by inhibiting IAPs but also require the expression of other downstream death effector proteins in order to kill cancer ...

由 S Hannes 著作 · 2021 · 被引用 16 次 — In the present study, we demonstrate that the DNA sensor STING can be engaged in PC cells to induce the expression of IFN responses. STING ...

2023年8月15日 — The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells · 外科部 ...